The effect of early irregular cell division of human embryos on blastocyst euploidy: Considerations from the subsequent development of the blastomeres by direct or reverse cleavage (2022年11月 F&S Science)
Shinichi Watanabe, Kaori Yoshikai, Yukino Matsuda, Shunsuke Miyai,

Yuki Sawada, Hiroki Kurahashi, Tomio Sawada



Objective: To investigate whether blastocysts that divide irregularly reduce subsequent blastocyst euploidy.

Design: Retrospective study.

Setting: Private clinic.

Patient(s): 122 blastocysts for which consent for disposal and research use were obtained.

Intervention(s): None.

Main Outcome Measure(s): Results of NGS analysis of the blastocysts and whether blastomeres by normal or irregular divisions subsequently participated in blastocyst formation or not.

Results: The embryos were classified according to their dynamics until the second cleavage. The blastocyst euploidy was 33.3% (19/57) in the normal cleavage (NC) group, 38.3% (18/47) in the direct cleavage (embryos with one cell dividing into three cells) (DC) group, and 72.2% (13/18) in the reverse cleavage (embryos with fused cells once divided) (RC) group. The rate of the RC group was significantly higher than that of the NC (P<0.05).

The blastocyst participation rate of the blastomeres were 95.6% in the NC group and 56.5% in that derived from DC of the first cleavage, and 91.7% in that of blastomeres derived from normal division of the second cleavage and 53.6% in that derived from DC of the second cleavage, both of which were significantly lower in the latter (P<0.01), and in the RC group, the rates of fused and non-fused blastomeres were 62.1% and 87.5%, respectively, with no significant difference.

Conclusion: The blastomeres generated by DC were often excluded from blastocyst formation, and we speculate that this is one reason why their division does not reduce blastocyst euploidy. The association between RC and euploidy of blastocysts merits further study.

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